Study on preparation of salvianolic acid phospholipid compound / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 216-221, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-319626
المكتبة المسؤولة:
WPRO
ABSTRACT
To prepare salvianolic acid phospholipid compound. With the compound of salvianolic acids and soybean phospholipid as the index, mono-factor experiment and orthogonal design experiment were conducted to screen its technical parameters. According to the results, the optimal preparation conditions of salvianolic acid phospholipid compound were that THF were taken as the reaction solvent, the concentration time was 3 h, the reactant concentration was 5 g x L(-1), the mass ratio of salvianolic acids and phospholipid was 1 1.5, and the reaction temperature was 40 degrees C. The oil/water partition coefficient of the prepared salvianolic acid phospholipid compound significant increased in water and buffers with different pH values. The results of phase analysis such as DSC, XRD and FTIR indicated that salvianolic acids existed in phospholipid in an amorphous state.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Phospholipids
/
Glycine max
/
Temperature
/
Chemistry
/
Chemistry, Pharmaceutical
/
Alkenes
/
Chemical Phenomena
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Polyphenols
/
Intestinal Absorption
/
Metabolism
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2014
نوع:
Article