Clinicopathologic study of parvovirus B19 infection in perinatal period / 中华病理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To characterize the risks and histopathological features of parvovirus B19 infection of infants in perinatal period.</p><p><b>METHODS</b>Routine pathological examination was performed on 1 neonate, 2 dead fetuses and 2 placentas using either autopsy or biopsy materials.</p><p><b>RESULTS</b>The diagnostic intranuclear inclusions were found in erythroblasts in the bone marrow, liver, spleen and lungs in one case, in the spleen and liver in one case, in the spleen in one case, and in the placentas in two cases.</p><p><b>CONCLUSIONS</b>Severe hemolytic anemia or fetal hydrop or hemophagocytosis caused by the infection of parvovirus B19 can lead to death of infected neonates and fetus. Pathological confirmation of parvovirus B19 infection relies on the identification of erythroblasts containing the diagnostic intranuclear inclusions.</p>