Research advances on hydrogen therapy in nervous system diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 638-643, 2010.
Article
ي Zh
| WPRIM
| ID: wpr-319845
المكتبة المسؤولة:
WPRO
ABSTRACT
Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases. Recent studies have demonstrated that hydrogen has selective antioxidative effect. It selectively reduces the hydroxyl radical (*OH) and peroxynitrite (ONOO(-)), the most cytotoxic of reactive oxygen species (ROS); however, it does not affect other ROS, which play important physiological roles at low concentrations. A large body of experimental studies has proved that hydrogen, through anti-oxidation, anti-inflammatory and inhibiting apoptosis, has a significant therapeutic effect in various neurological diseases, such as ischemia, hypoxia, degeneration and spinal cord contusion. It provides us with a new clinical method for the prevention and treatment of neurological diseases.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Physiology
/
Hydroxyl Radical
/
Oxidative Stress
/
Peroxynitrous Acid
/
Drug Therapy
/
Hydrogen
/
Metabolism
/
Nervous System
/
Nervous System Diseases
المحددات:
Humans
اللغة:
Zh
مجلة:
Journal of Zhejiang University. Medical sciences
السنة:
2010
نوع:
Article