Single and combined effects of estrone and 17β-estradiol on male goldfish / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 176-184, 2013.
Article
ي En
| WPRIM
| ID: wpr-320353
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the single and combined effects of estrone (E1) and 17β-estradiol (E2) on goldfish (Carassius auratus).</p><p><b>METHODS</b>Batch tests were conducted. Serum levels of vitellogenin (VTG) and E2, gonadosomatic indices (GSI), gonadal DNA damage and liver 7-ethoxyresorufin-O-deethylase (EROD) activity were measured after exposure for 14 days.</p><p><b>RESULTS</b>The VTG level increased significantly in a concentration-dependent manner. The serum E2 level was significantly higher and the GSI level was significantly lower in goldfish after exposed to the 3 drugs. DNA damage occurred in treated samples and EROD activity was significantly suppressed 7 days after exposure. The joint effect of E1 and E2 was additive with regard to VTG induction.</p><p><b>CONCLUSION</b>The results of our study highlight a series of effects of steroidal estrogens on goldfish. Further study is needed to confirm their effect as a whole.</p>
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
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Blood
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DNA Damage
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Goldfish
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Vitellogenins
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Cytochrome P-450 CYP1A1
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Drug Combinations
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Estradiol
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Estrone
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Gonads
المحددات:
Animals
اللغة:
En
مجلة:
Biomedical and Environmental Sciences
السنة:
2013
نوع:
Article