Analysis of 32 cases of acute leukemia with abnormality of chromosome 7 / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 596-599, 2004.
Article
ي Zh
| WPRIM
| ID: wpr-321187
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the incidence and prognostic significance of chromosome 7 anomaly in acute leukemia.</p><p><b>METHODS</b>Conventional cytogenetic analysis of R-band was used to detect the abnormalities of chromosome 7 in 410 acute leukemia patients.</p><p><b>RESULTS</b>Thirty-two cases (7.8%) with abnormalities of chromosome 7, of which 19 (59.4%) had -7/7q-; 3(9.4%) had t(7;11); and the rest had other abnormalities such as der(7), +7, t(2;7), t(5;7), t(7;9), t(7;8) and dic(1;7). The incidence of -7/7q- in M0, M1 and M2 was higher than that in other subtypes of acute myeloid leukemia (AML). Twenty cases had additional cytogenetic aberrations, such as t(9;22) with -7, +8, -5. In 30 cases treated with chemotherapy, 11 cases acquired complete remission (CR) and the CR rate was lower than that for all concurrent cases of acute leukemia(36.7% vs 65.8%); the CR rate of AML with -7/7q- was lower than that of AML with normal karyotype(25% vs 55.6%). There was no difference in the CR rate between acute lymphocytic leukemia(ALL) with -7/7q- and ALL with normal chromosome (57.1% vs 77.8%), but 4 cases with -7/7q- which attained complete remission for a time relapsed early. In other 11 patients with additional chromosome 7 aberration, only 4 patients acquired CR.</p><p><b>CONCLUSION</b>-7/7q- was the frequent aberration in chromosome 7 anomaly, which was often detected in M0, M1 and M2. It might be associated with the pathogenesis of acute leukemia; the patients with chromosome 7 anomaly had poorer prognosis.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prognosis
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Vincristine
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Chromosomes, Human, Pair 7
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Prednisone
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Leukemia, Myeloid, Acute
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Antineoplastic Combined Chemotherapy Protocols
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Doxorubicin
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Chromosome Aberrations
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Cyclophosphamide
/
Therapeutic Uses
نوع الدراسة:
Prognostic_studies
المحددات:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Medical Genetics
السنة:
2004
نوع:
Article