Prognostic Analysis of 102 Patients with Synchronous Colorectal Cancer and Liver Metastases Treated with Simultaneous Resection / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1283-1289, 2017.
Article
ي En
| WPRIM
| ID: wpr-330628
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>The liver is the most common site for colorectal cancer (CRC) metastases. Their removal is a critical and challenging aspect of CRC treatment. We investigated the prognosis and risk factors of patients with CRC and liver metastases (CRCLM) who underwent simultaneous resections for both lesions.</p><p><b>METHODS</b>From January 2009 to August 2016, 102 patients with CRCLM received simultaneous resections of CRCLM at our hospital. We retrospectively analyzed their clinical data and analyzed their outcomes. Overall survival (OS) and disease-free survival (DFS) were examined by Kaplan-Meier and log-rank methods.</p><p><b>RESULTS</b>Median follow-up time was 22.7 months; no perioperative death or serious complications were observed. Median OS was 55.5 months; postoperative OS rates were 1-year 93.8%, 3-year 60.7%, and 5-year 46.4%. Median DFS was 9.0 months; postoperative DFS rates were 1-year 43.1%, 3-year 23.0%, and 5-year 21.1%. Independent risk factors found in multivariate analysis included carcinoembryonic antigen ≥100 ng/ml, no adjuvant chemotherapy, tumor thrombus in liver metastases, and bilobar liver metastases for OS; age ≥60 years, no adjuvant chemotherapy, multiple metastases, and largest diameter ≥3 cm for DFS.</p><p><b>CONCLUSIONS</b>Simultaneous surgical resection is a safe and effective treatment for patients with synchronous CRCLM. The main prognostic factors are pathological characteristics of liver metastases and whether standard adjuvant chemotherapy is performed.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prognosis
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General Surgery
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Colorectal Neoplasms
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Retrospective Studies
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Mortality
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Treatment Outcome
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Disease-Free Survival
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Hepatectomy
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Liver Neoplasms
نوع الدراسة:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
المحددات:
Adult
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Aged
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Female
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Humans
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Male
اللغة:
En
مجلة:
Chinese Medical Journal
السنة:
2017
نوع:
Article