Clinical analysis of 12 patients with angioimmunoblastic T cell lymphoma / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1208-1210, 2010.
Article
ي Zh
| WPRIM
| ID: wpr-332391
المكتبة المسؤولة:
WPRO
ABSTRACT
To evaluate the clinical, pathological characters and prognosis of patients with angioimmunoblastic T cell lymphoma (AITL), the clinicopathologic features, immunophenotypes, therapy and survival rate of 12 AITL patients which were confirmed by pathologic examination were retrospectively studied. The results indicated that main symptom was observed as general lymphadenopathy, however, 9 patients had fever. The diagnosis of AITL was based on lymph-node biopsy. The histopathologic characteristics of AITL showed the damage of normal lymphnode structure, the proliferation of immunoblastic cells and arborescent super vascularization. All immunophenotypes were mature peripheral T-cellular. CVP regimen was the most common chemotherapy regimen used for patients. 58% patients have a good initial response to chemotherapy. 3-year survival was 25%, with median survival time of 25 months. In conclusion, most cases of AITL display an aggressive course, therefore, the disease progresses rapidly and has unfavorable prognosis, further studies are required to improve its therapy regimen.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
/
Therapeutics
/
Survival Rate
/
Lymphoma, T-Cell, Peripheral
/
Diagnosis
/
Immunoblastic Lymphadenopathy
/
Lymph Nodes
نوع الدراسة:
Diagnostic_studies
/
Prognostic_studies
المحددات:
Aged
/
Female
/
Humans
/
Male
اللغة:
Zh
مجلة:
Journal of Experimental Hematology
السنة:
2010
نوع:
Article