The clinical value of F-18 FDG PET/CT in patients with secondary hemophagocytic syndrome / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1698-1701, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-340434
المكتبة المسؤولة:
WPRO
ABSTRACT
The aim of this study was to investigate the role of F-18 fluoro-2-deoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in diagnosis and prognostic evaluation of secondary hemophagocytic syndrome (HPS). A total of 11 secondary HPS patients examined with 18F-FDG-PET/CT were retrospectively analyzed. The diagnostic value of F-18 FDG PET/CT for malignancy detection was assessed. The values of maximum standardized uptake value (SUV(max)) in spleen (SUVS(p)) and in bone marrow (SUVBM) were measured to analyze their relationship with various laboratorial parameters and clinical outcome of secondary HPS patients. The results showed that 4 out of the 11 patients had malignancies, the sensitivity, specificity and diagnostic accuracy of F-18 FDG PET/CT for malignancy detection were 100%, 66.7% and 75% respectively, the SUV(max) of spleen and bone marrow showed no significant correlation with laboratorial parameters, a maximum SUVS(p) of 3.10 and a maximum SUVBM of 3.47 were the optimal cutoffs for predicting patients' outcome, the increased uptake of F-18 FDG in the BM and spleen were significantly associated with shorter survival time according to univariate analysis. It is concluded that 18F-FDG PET/CT may especially play an important role in diagnosis and predicting outcome of secondary HPS for the small sample size.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prognosis
/
Diagnostic Imaging
/
Tomography, X-Ray Computed
/
Retrospective Studies
/
Fluorodeoxyglucose F18
/
Positron-Emission Tomography
/
Lymphohistiocytosis, Hemophagocytic
/
Multimodal Imaging
نوع الدراسة:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
المحددات:
Humans
اللغة:
Zh
مجلة:
Journal of Experimental Hematology
السنة:
2014
نوع:
Article