Correlation between APOA gene polymorphism and intracranial aneurysm / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 31-34, 2005.
Article
ي Zh
| WPRIM
| ID: wpr-343772
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the correlation between a pentanucleotide repeats (PNR) polymorphism of APOA and the genesis of intracranial aneurysm.</p><p><b>METHODS</b>Fifty-eight patients with intracranial aneurysms diagnosed by angiography and 58 healthy controls were enrolled in our study. The gene polymorphism of APOA PNR were detected by polymerase chain reaction (PCR) and non-denatured polyacrylamide gels electropherosis (PAGE).</p><p><b>RESULTS</b>Eight kinds of gene types and 6 kinds of alleles were found in these two groups. There were two sites of sequence variance in the 5' control region of APOA gene, which were significantly different between the patients and controls.</p><p><b>CONCLUSION</b>Correlation may exist between intracranial aneurysm and APOA gene.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Apolipoproteins A
/
Polymorphism, Genetic
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DNA
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Intracranial Aneurysm
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Microsatellite Repeats
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Asian People
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Alleles
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Gene Frequency
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Genetics
/
Genotype
المحددات:
Adult
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Aged
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Acta Academiae Medicinae Sinicae
السنة:
2005
نوع:
Article