LEDGF/p75: a novel target for anti-HIV therapy and advances in the study of its related inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 953-960, 2009.
Article
ي Zh
| WPRIM
| ID: wpr-344013
المكتبة المسؤولة:
WPRO
ABSTRACT
LEDGF/p75 is a newly found cell cofactor, which plays an essential role in the integration of HIV-1 cDNA into host chromosomes. LEDGF/p75 tethers HIV integrase to chromatin, protects it from degradation, and strongly influences the genome-wide pattern of HIV integration. Depleting the protein from cells or over-expressing the integrase-binding domain of LEDGF/p75 blocks viral replication. The essential role of LEDGF/p75 in HIV-1 replication makes it a new target for anti-HIV-1 drug development. This article reviews the function of LEDGF/p75, LEDGF/p75-integrase interaction and LEDGF/p75 inhibitors.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Physiology
/
Protein Binding
/
Chemistry
/
HIV-1
/
HIV Integrase
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Anti-HIV Agents
/
Intercellular Signaling Peptides and Proteins
/
Metabolism
اللغة:
Zh
مجلة:
Acta Pharmaceutica Sinica
السنة:
2009
نوع:
Article