CADASIL with clinical manifestations of baldness, lumbago and Parkinson's symptoms / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 821-825, 2017.
Article
ي Zh
| WPRIM
| ID: wpr-344168
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate a cerebral autosomal dominant arteriopathy with the subcortical infarcts and leukoencephalopathy (CADASIL) case with clinical manifestations of baldness, lumbago and Parkinson's symptoms.</p><p><b>METHODS</b>Clinical and imaging data of the patient were analyzed. The patient and his family members were also subjected to genetic testing.</p><p><b>RESULTS</b>The symptoms of the patient included recurrent stroke, dementia, and mood disturbance, in addition with lumbago, baldness and Parkinson's symptoms but no migraine. Cranial MRI of the patient showed bilateral symmetric leukoencephalopathy and multiple small subcortical lacunar infarcts. A point mutation in exon 11 of the NOTCH3 gene (R558C) was discovered in the proband and four asymptomatic relatives.</p><p><b>CONCLUSION</b>CADASIL is characterized by recurrent subcortical ischemic stroke, dementia, pseudobulbar palsy, and mood disturbance. Baldness, lumbago and Parkinson's symptoms may also be seen in such patients.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Diagnostic Imaging
/
Magnetic Resonance Imaging
/
Low Back Pain
/
Parkinsonian Disorders
/
CADASIL
/
Alopecia
/
Receptor, Notch3
/
Genetics
/
Mutation
نوع الدراسة:
Diagnostic_studies
المحددات:
Humans
/
Male
اللغة:
Zh
مجلة:
Chinese Journal of Medical Genetics
السنة:
2017
نوع:
Article