Prognostic role of the ABO blood types in Chinese patients with curatively resected non-small cell lung cancer: a retrospective analysis of 1601 cases at a single cancer center / 癌症
Chinese Journal of Cancer
; (12): 475-482, 2015.
Article
ي En
| WPRIM
| ID: wpr-349564
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>A positive association between the ABO blood types and survival has been suggested in several malignancies. The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of Chinese patients with curatively resected non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>We retrospectively analyzed 1601 consecutive Chinese patients who underwent curative surgery for NSCLC between January 1, 2005 and December 31, 2009. The relationship between the ABO blood types and survival was investigated. In addition, univariate and multivariate analyses were performed.</p><p><b>RESULTS</b>Group 1 (patients with the blood type O or B) had significantly prolonged overall survival (OS) compared with group 2 (patients with the blood type A or AB), with a median OS of 74.9 months versus 61.5 months [hazard ratio (HR) 0.83; 95% confidence interval (CI) 0.72-0.96; P = 0.015]. Additionally, group 1 had significantly longer disease-free survival (DFS; HR 0.86; 95% CI 0.76-0.98; P = 0.022) and locoregional relapse-free survival (LRFS; HR 0.79; 95% CI 0.64-0.98; P = 0.024) than group 2. The association was not significantly modified by other risk factors for NSCLC, including smoking status, pathologic tumor-node-metastasis stage, pT category, pN category, and chemotherapy.</p><p><b>CONCLUSIONS</b>There is an association between the ABO blood types and the survival of Chinese patients with resected NSCLC. Patients with the blood type O or B had significantly prolonged OS, DFS, and LRFS compared with those with the blood type A or AB.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prognosis
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ABO Blood-Group System
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Multivariate Analysis
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Retrospective Studies
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Risk Factors
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Carcinoma, Non-Small-Cell Lung
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Disease-Free Survival
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Asian People
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Neoplasm Recurrence, Local
نوع الدراسة:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
المحددات:
Humans
اللغة:
En
مجلة:
Chinese Journal of Cancer
السنة:
2015
نوع:
Article