The influence of hepatitis B virus infection on patients undergoing allogeneic hematopoietic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology
; (12): 456-460, 2010.
Article
ي Zh
| WPRIM
| ID: wpr-353577
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the prognosis and hepatitis B serologic marker changes in patients with HBV infection or with HBV infected donors after allogenic hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>The clinical outcomes of 79 patients receiving allo-HSCT, including 55 with HBV infection and 24 from HBV infected donors were analyzed retrospectively.</p><p><b>RESULTS</b>(1) HBV infection did not interfere with the clinical outcome of allo-HSCT. (2) In 20 HBsAg(+) patients, 13(65.0%) developed HBV reactivation between 0.5 and 10 months after transplantation, 9(45.0%) developed HBV-related hepatitis. (3) For the 35 HBsAg(-) and HBcAb/HBeAb positive patients, 4 (11.4%) occurred HBV seroconversion, 1 of the 4 complicated with severe chronic graft-versus-host disease (cGVHD). (4) There was a significant difference in HBV reactivation rate between the HBsAg(+) and HBsAg-groups (P < 0.01). The incidence of hepatitis occurred within 100 days after HSCT was high in HBsAg(+) patients (P < 0.05). (5) Clearance of HBsAg was observed in 2 HBsAg(+) patients, both of whom received graft from HBsAb positive donors.</p><p><b>CONCLUSIONS</b>Donors or recipients infected with HBV is not considered an absolute contraindication for HSCT, but HBsAg positivity is a high risk factor for HBV reactivation and prophylactic lamivudine treatment may be helpful. For patients with HBcAb/HBeAb positivity, seroconversion can be observed, especially after immunosuppressant withdrawal. Adoptive immunity is effective in clearing HBV in these patients.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Hepatitis B virus
/
Epidemiology
/
Hematopoietic Stem Cell Transplantation
/
Hepatitis B
/
Hepatitis B Antibodies
/
Hepatitis B Surface Antigens
نوع الدراسة:
Prognostic_studies
المحددات:
Humans
اللغة:
Zh
مجلة:
Chinese Journal of Hematology
السنة:
2010
نوع:
Article