Serratia marcescens vaccine in the treatment of malignant pleural effusion / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 188-190, 2002.
Article
ي Zh
| WPRIM
| ID: wpr-354038
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of Serratia marcescens (S311) vaccine in the treatment of malignant pleural effusion.</p><p><b>METHODS</b>Thirty-four patients with malignant pleural effusion were given S311 as intrapleural injection with a dose of 10(9) U (0.32 mg) on D 1, 8 and 15, and observed for four weeks.</p><p><b>RESULTS</b>The overall response rate (CR + PR) was 97.1% (CR in 12 patients and PR in 21 patients). The systemic toxicity was mild, including fever (82.4%), pleuritic pain (50.7%), nansea (26.5%), dyspnea (17.5%) and chills (5.9%).</p><p><b>CONCLUSION</b>Serratia marcescens vaccine is effective for malignant pleural effusion, with tolerable toxic effects. Further study is warranted.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pleural Effusion
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Serratia marcescens
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Time Factors
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Chest Pain
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Bacterial Vaccines
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Treatment Outcome
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Therapeutic Uses
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Dose-Response Relationship, Drug
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Drug Therapy
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Allergy and Immunology
المحددات:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Oncology
السنة:
2002
نوع:
Article