Advancement of Reovirus-based therapy for cancer / 国际肿瘤学杂志
Journal of International Oncology
; (12): 514-517, 2010.
Article
ي Zh
| WPRIM
| ID: wpr-387456
المكتبة المسؤولة:
WPRO
ABSTRACT
Reovirus,a kind of oncolytic viruses, is seldom pathogenic, but is selectively able to replicate in cancer cells through activation of Ras signaling. Pre-clinical studies have demonstrated that treatment with reovirus is associated with significant anticancer activity across a range of tumor types. Further clinical evaluation of reovirus therapy has shown that it is well tolerated when administered locally or systemically. Encouraging anticancer efficacy has been observed with single-agent treatment and in combination with chemotherapy and radiotherapy. High safety and promising efficacy of reovirus has raised hopes that it will become a new anticancqt agent.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Journal of International Oncology
السنة:
2010
نوع:
Article