MicroRNA and preoperative diagnosis of papillary thyroid carcinoma / 国际肿瘤学杂志

ABSTRACT

MicroRNAs(miRNAs)are a class of small noncoding RNA molecules that function as posttranscriptional gene regulators by base-pairing with their target mRNAs where they either repress translation or direct destructive cleavage.Recent evidences have shown that miRNAs were aberrantly expressed in papillary thyroid carcinoma(PTC)compared with normal thyroid tissue,indicating that they may play a crucial role in the initiation and progression of PTC.Some deregulated miRNAs might potentially be adjunct markers in the preoperative diagnosis of papillary thyroid carcinoma.