Effect of large dose of magnesium sulfate on patients with brain injury / 中华创伤杂志

ABSTRACT

Objective　To explore the efficacy of large dose of magnesium sulfate used to treat patients with brain trauma. 　Methods　According to standards 32 patients were chosen and divided into experimental group and control group at random. Sixteen patients in experimental group received 16 mmol magnesium sulfate intravenously over 15 minutes, followed by 65 mmol over 24 hours; while 16 patients in control group received nothing. Serum NSE, GCS and GOS of all the patients were measured after 3 days, 2 weeks and 6 months, respectively and the data were analyzed statistically. 　Results　The serum NSE, GCS and GOS in experimental group were (24.8±19.2) μg/L, 12.3±3.3 and 3.6±1.4, respectively; while the serum NSE, GCS and GOS in control group were (49.7±23.1) μg/L, 9.8±2.8 and 3.1±1.6, respectively. Between the two groups the serum NSE and GCS were different significantly (P<0.01, P<0.05, respectively) while the GOS was not (P>0.05).　 Conclusions　Large dose of magnesium sulfate is effective to treat patients with brain injury at least within a short term.