Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES 2008-2010)
Yonsei Medical Journal
; : 944-950, 2015.
Article
ي En
| WPRIM
| ID: wpr-40870
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE: Blood mercury levels are associated with inflammation, and chronic low-grade inflammation is a cause of insulin resistance. This study aimed to investigate the association between serum mercury and insulin resistance. MATERIALS AND METHODS: Subjects from the 2008-2010 Korean National Health and Nutrition Examination Survey were selected (n=29235) and the relevant data of 5388 subjects (2643 males and 2745 females) were analyzed cross-sectionally. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) was compared according to blood mercury quartiles, and the odds ratio (OR) of having the highest quartile of HOMA-IR according to blood mercury quartiles was calculated. RESULTS: Blood mercury levels in men and women were 29.4 nmol/L and 20.5 nmol/L, respectively, and fasting blood sugar (FBS), insulin, and HOMA-IR were significantly correlated with blood mercury levels. The correlation was stronger in men than in women. In men, FBS and HOMA-IR showed step-wise increases as the quartiles of blood mercury increased; only HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. In women, however, both FBS and HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. Among men, the OR of being in the highest HOMA-IR quartile was greatest for the highest blood mercury quartile (OR=1.720, 95% CI; 1.172-2.526), compared with the lowest quartile. CONCLUSION: In this large population-based study, blood mercury levels were weakly correlated with HOMA-IR and may be a risk factor for insulin resistance in nondiabetic Koreans.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Insulin Resistance
/
Odds Ratio
/
Nutrition Surveys
/
Cross-Sectional Studies
/
Risk Factors
/
Asian People
/
Republic of Korea
/
Insulin
/
Mercury
نوع الدراسة:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Adult
/
Female
/
Humans
/
Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Yonsei Medical Journal
السنة:
2015
نوع:
Article