Clinical Prognostic Factors and Treatment Outcome of Aggressive Non-Hodgkin's Lymphoma in Elderly Patients / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 324-328, 2001.
Article
ي Ko
| WPRIM
| ID: wpr-41068
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE: The aim of this study was to determine the prognostic factors and treatment outcome of for elderly patients (age>or=60 at time of diagnosis) with aggressive non-Hodgkin's lymphoma (NHL). MATERIALS AND METHODS: We analyzed 52 patients diagnosed with aggressive NHL between January 1990 and May 2000. RESULTS: The patient's median age was 69 years (range: 60~92). Thirty-two (61.5%) patients were male. Patients included those with diffuse large B cell (53.8%), peripheral T cell (23.1%), AILD-like T-cell (3.8%), angiocentric (3.8%), mantle cell (3.8%), Burkitt's lymphoma (3.8%), and others (7.9%). International prognostic index (IPI) parameters were as follows: elevated LDH (60.8%), ECOG performance status>or=2 (32.7%), advanced stage (III/IV, 62.7%), and extranodal site>or=2 (11.5%). Twenty-six (50.0%) patients demonstrated a high and high-intermediate IPI. The median follow-up for surviving patients was 26.6 months. The overall median survival was 22.7 months and the 2-year survival rate was 46.9%. Among the 49 patientstreated with chemotherapy, 28 (57.1%) patients achieved complete remission (CR). Univariate analysis identified 8 prognostic factors for overall survival: ageor=60 years) with aggressive NHL can be successfully treated with conventional chemotherapy and the important prognostic factors for survival are age, IPI, initial WBC, and CR on first line treatment.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Lymphoma, Non-Hodgkin
/
T-Lymphocytes
/
Multivariate Analysis
/
Survival Rate
/
Follow-Up Studies
/
Burkitt Lymphoma
/
Treatment Outcome
/
Drug Therapy
/
Lymphoma
نوع الدراسة:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Aged
/
Humans
/
Male
اللغة:
Ko
مجلة:
Cancer Research and Treatment
السنة:
2001
نوع:
Article