Estrogen receptor β and breast cancer / 肿瘤研究与临床

ABSTRACT

Breast cancer is a hormone-dependent malignant carcinoma. Many well-established studies have shown estrogen receptor , especially estrogen receptor alpha (ERα), play an important role in the development of breast cancer. Recently, increasing evidences have shown that another subtype of estrogen receptor,estrogen receptor beta (ER β), may play an important role in the development of breast cancer. In contrast to the function of ERa, ER β played an anti-proliferation role in cell model and animal experiments of breast cancer. We review the recent articles on the relationship between ERB and invasion and metastasis of breast cancer, the coexpression and interaction among ERβ , ERα and PR.