The neuroprotective effect of colloids in forebrain ischemia model
Anesthesia and Pain Medicine
; : 338-342, 2012.
Article
ي En
| WPRIM
| ID: wpr-41600
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND:
The aim of this study was to investigate the neuroprotective effects of colloids (albumin and pentastarch) after forebrain global ischemia in rats.METHODS:
Thirty male Sprague-Dawley rats were randomly assigned to three groups; control, albumin and pentastarch group (each n = 10). Forebrain ischemia was induced by bilateral common carotid artery occlusion plus hemorrhagic hypotension. The control group received no treatment. The albumin group received 5 ml/kg of 20% albumin after ischemia. The pentastarch group received same volume of albumin after ischemia. Histologic outcomes were measured at 7 days after ischemia in CA1 pyramidal cells of the rat hippocampus.RESULTS:
The mean percentage of viable cells in the hippocampal CA1 area was significantly higher in the albumin (47%) compared with the control group (33%) or pentastarch group (33%) (P = 0.001). The percentage of apoptotic cells was significantly lower in the albumin (30%) group than that in the pentastarch (44%) or control group (49%) (P = 0.006).CONCLUSIONS:
This study shows that albumin can improve histologic outcomes after forebrain global ischemia compared with pentastarch.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Brain Ischemia
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Hydroxyethyl Starch Derivatives
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Prosencephalon
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Rats, Sprague-Dawley
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Carotid Artery, Common
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Pyramidal Cells
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Colloids
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Neuroprotective Agents
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Hippocampus
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Hypotension
المحددات:
Animals
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Humans
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Male
اللغة:
En
مجلة:
Anesthesia and Pain Medicine
السنة:
2012
نوع:
Article