Application of deformable registration and empirical calculation method to calculate the accumulated dose for normal tissues and organs at risks in lung cancer radiotherapy plans / 中华放射医学与防护杂志

ABSTRACT

Objective To evaluate the accumulated doses to normal tissues and organs at risks (OARs) of patients with lung cancer in radiotherapy plans by using the deformable registration method,and make comparison with the empirical calculation method.Methods Ten patients with lung cancer were analyzed retrospectively.3D-CRT or IMRT plans were designed before treatment. CT to simulator was rescanned and the same treatment plan was redesigned during radiotherapy. Based on the deformable registration method,the Mimvista software was used to calculate the accumulated doses to normal tissues and OARs in two CT images respectively.The empirical estimation algorithm was calculated by the linear relationship between the fractions and the total prescribed dose.Results The target coverage of patients had no significant difference in two plans.There were no significant differences in all the dose volume parameters for normal tissues and OARs,except the mean dose to right lung( t =2.98,P ＜ 0.05 ) when the the same plan was conducted in position-setting and reposition CT images.Conclusions The empirical estimation for the accumulated dose could be used to evaluate the dose and volume parameters for normal tissues and OARs in lung cancer by the same plan.