Changes of bone metabolic biochemical markers and bone mineral density in patients of Graves disease with different courses / 中华全科医师杂志

ABSTRACT

A total of 144 patients with Graves disease were divided into 3 groups according to their disease courses (≤ 1 year,1 year ＜ course ≤ 5 years,＞ 5 years).The bone metabolic biochemical markers and bone mineral density (BMD) of 144 patients with Graves disease and 26 normal controls were observed.Compared with control group,serum levels of calcium,phosphate,alkaline phosphatase and urinary levels of phosphate and magnesium in Graves disease patients were significantly increased(P ＜ 0.01 or P ＜ 0.05),but serum levels of magnesium and 25 (OH) D3,1,25 (OH)2D3 were significantly decreased (P ＜ 0.01 or P ＜ 0.05).BMD of all sites in patients were significantly lower than that of normal controls (P ＜ 0.01 or P ＜ 0.05).