Increase in dietary protein content exacerbates colonic inflammation and tumorigenesis in azoxymethane-induced mouse colon carcinogenesis
Nutrition Research and Practice
; : 281-289, 2017.
Article
ي En
| WPRIM
| ID: wpr-44075
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND/OBJECTIVE:
The incidence of colorectal cancer (CRC) has been attributed to higher intake of fat and protein. However, reports on the relationship between protein intake and CRC are inconsistent, possibly due to the complexity of diet composition. In this study, we addressed a question whether alteration of protein intake is independently associated with colonic inflammation and colon carcinogenesis. MATERIALS/METHODS:
Balb/c mice were randomly divided into 4 experimental groups 20% protein (control, 20P, 20% casein/kg diet), 10% protein (10P, 10% casein/kg diet), 30% protein (30P, 30% casein/kg diet), and 50% protein (50P, 50% casein/kg diet) diet groups and were subjected to azoxymethane-dextran sodium sulfate induced colon carcinogenesis.RESULTS:
As the protein content of the diet increased, clinical signs of colitis including loss of body weight, rectal bleeding, change in stool consistency, and shortening of the colon were worsened. This was associated with a significant decrease in the survival rate of the mice, an increase in proinflammatory protein expression in the colon, and an increase in mucosal cell proliferation. Further, colon tumor multiplicity was dramatically increased in the 30P (318%) and 50P (438%) groups compared with the control (20P) group.CONCLUSIONS:
These results suggest that a high protein diet stimulates colon tumor formation by increasing colonic inflammation and proliferation.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Sodium
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Body Weight
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Dietary Proteins
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Colorectal Neoplasms
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Caseins
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Incidence
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Survival Rate
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Colitis
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Colon
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Colonic Neoplasms
نوع الدراسة:
Incidence_studies
/
Prognostic_studies
المحددات:
Animals
اللغة:
En
مجلة:
Nutrition Research and Practice
السنة:
2017
نوع:
Article