Secretion of adipokines in miR-26b over-expressed human adipocytes differentiation process / 临床儿科杂志
Journal of Clinical Pediatrics
; (12): 914-916, 2013.
Article
ي Zh
| WPRIM
| ID: wpr-441243
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective To investigate the inlfuence of overexpression of miR-26b on the secretion of adipokines dur-ing human adipocyte differentiation. Methods Human preadipocytes were infected with the hsa-miR-26b over-expressing lentivirus and were induced to differentiate, and then the levels of adipokines (IL-6, leptin, resistin, TNF-α) at different time points during differentiation were measured by ELISA. Results Compared with control group, decreased secretions of both IL-6 and leptin, and increased secretion of resistin were found during the differentiation of human adipocytes in miR-26b overexpressed group. However, the secretion of TNF-αwas not measured in both groups. Conclusion The miR-26b can improve the inlfammation and insulin resistance of human adipocytes, which will provide potential targets for obesity treat-ment.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Journal of Clinical Pediatrics
السنة:
2013
نوع:
Article