Correlation between cervical lesion development and histone acetylation modification that regulates RAR-β2 expression / 中国肿瘤临床
Chinese Journal of Clinical Oncology
; (24): 300-304, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-443873
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective:
To investigate the relationship between cervical lesion development and histone acetylation that regulates RAR-β2 expression.Methods:
Immunohistochemistry and Western blot analysis were performed to detect AcH3, RAR-β2, and involu-crin expression in normal cervical tissues as well as in tissues with cervical intraepithelial neoplasia (CIN)Ⅱ-Ⅲand squamous cell cer-vical carcinoma. The relationship among histone acetylation level, RAR-β2 expression, and cervical lesion severity were analyzed. Re-sultsAcH3, RAR-β2, and involucrin expression were reduced or absent with the progression of cervical lesions;significant differences were noted between the groups (P<0.05). Histone acetylation level and RAR-β2 expression were positively correlated (r=0.797, P<0.05). AcH3 and RAR-β2 expression, which were both associated with the cervical lesions, were negatively correlated [r=-0.547(AcH3), r=-0.585(RAR-β2), P<0.05].Conclusion:
Histone acetylation modification is associated with the regulation of RAR-β2 expression. This pro-cess is also likely to participate in the carcinogenesis of cervical carcinoma.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Chinese Journal of Clinical Oncology
السنة:
2014
نوع:
Article