Quality Control of Residual Solvents in 18FFDG Preparations by Gas Chromatography / 핵의학분자영상

ABSTRACT

PURPOSE: Analysis of volatile organic solvents in 2-deoxy-2-[18F] fluoro-D-glucose ([18F]FDG) preparations was performed by gas chromatography (GC), in accordance with USP. MATERIALS AND METHODS: Analyses were carried out on a Hewlett-Packard 6890 gas chromatography equipped with an FID. RESULTS: We determined the amounts of ethanol and acetonitrile on every batch of our routine [18F]FDG preparations, ranging between 5000 ppm and 100 ppm. In our routine preparation of [18F]FDG, the amount of acetonitrile and ethanol in the final product were well below the maximum allowable limit described in the USP. CONCLUSION: Our [18F]FDG preparations were in accordance with the suggested USP maximum allowable levels of the quality control analysis of volatile organic compounds.