An investigation of therapeutic effect of Danhong injection combined with edaravone for treatment of patients with acute cerebral infarction / 中国中西医结合急救杂志

ABSTRACT

Objective To observe the clinical therapeutic effect of Danhong injection combined with edaravone for treatment of patients with acute cerebral infarction. Methods A prospective study was conducted. Two hundred and ten patients with acute cerebral infarction admitted to Traditional Chinese Medicine Hospital of Qinghai Province from June 2008 to January 2014 were divided into control group and observation group according to random number table method, 105 cases in each group. The conventional routine treatment and edaravone injection were given to the two groups, and additionally in the observation group, intravenous drip of Danhong injection 30 mL, once a day was applied, the therapeutic course in the two groups being 14 days. The changes of blood rheology, blood fat, the United States National Institutes of Health Stroke Scale (NIHSS) scores before and after treatment and clinical curative effect were observed in two groups. Results Compared with those before treatment, plasma viscosity, fibrinogen (Fib), erythrocyte hematocrit (HCT), total cholesterol (TC), triacylglycerol (TG),and NIHSS scores were decreased in the two groups after treatment, the decrease of the above indexes in observation group being more marked [plasma viscosity (mPa·s) 1.54±0.62 vs. 3.10±0.58, Fib (g/L) 3.87±0.91 vs. 4.81±1.31, HCT 0.46±0.04 vs. 0.54±0.05, TC (mmol/L) 4.97±1.73 vs. 6.65±1.62, TG (mmol/L) 5.01±1.25 vs. 7.53±1.23, NIHSS scores 2.31±1.15 vs. 10.23±2.21, all P<0.05];the statistical significant differences were found in the above indexes between observation group and control group after treatment [plasma viscosity (mPa·s )1.54±0.62 vs. 3.01±0.72, Fib (g/L)3.87±0.91 vs. 4.68±1.37, HCT0.46±0.04 vs. 0.52±0.04, TC (mmol/L)4.97±1.73 vs. 6.34±1.71, TG (mmol/L)5.01±1.25 vs. 7.51±1.30, NIHSS score2.31±1.15 vs. 3.75±1.73, P<0.05 or P<0.01]. The total effective rate in observation group was obviously higher than that of control group [97.14%(102/105) vs. 74.29%(78/105), P<0.01]. Conclusion The therapeutic effect of Danhong injection combined with edaravone for treatment of patients with acute cerebral infarction is significantly better than the treatment of edaravone injection alone.