Effect of somatostatin on the curative effect of laparoscopic operation in treatment of adhesive intestinal obstruction / 中国生化药物杂志

ABSTRACT

Objective To investigate somatostatin effect of on curative effect of laparoscopic operation in treatment of adhesive intestinal obstruction.Methods 80 patients with adhesive intestinal obstruction from January 2013 to May 2014, were randomly divided into control group and observation group, 40 cases in each group; the control group: treated with laparoscopic operation at the same time, from the patients admitted to the hospital after the foundation treatment; the observation group: somatostatin injection based on the treatment in control group.To observe the therapeutic effect of two groups, gastrointestinal decompression drainage, anal exhaust time, hospitalization time, the rate of conversion to surgical operation, postoperative analgesia, postoperative complications, follow-up treatment within 1 years after the recurrence rate, and application of functional EORTC life quality evaluation of the quality of life of two groups of patients with postoperative score.Results After treatment, the total effective rate of control group was 85%, the total efficiency of observation group was 92.50%, but the difference was not statistically significant (χ2 =2.635).After treatment, patients in observation group,the amount of gastrointestinal decompression, intestinal peristalsis recovery time, anal exhaust time, hospitalization time surgical operation and transfer rate were significantly lower than control group (P<0.01).By measuring the quality of life of EORTC scores between two groups, the observation group was significantly higher than the control group, there was significant difference ( P <0.01 ) .The success rate of the operation of the two groups was 100%, the observation group recurrence after 1 years of follow-up, the number of analgesic were significantly lower than the control group, there were significant differences.Complications in the observation group compared with the control group, the difference was not statistically significant (χ2 =2.813).Conclusion Laparoscopic operation in treatment of adhesive intestinal obstruction, given somatostatin can improve the clinical curative effect, shorten the recovery time of patients, reduce the recurrence rate, improve the survival of treatment.