Insulin signaling pathway and glucose metabolism in Alzheimer′s diseases / 国际药学研究杂志
Journal of International Pharmaceutical Research
; (6): 26-32, 2016.
Article
ي Zh
| WPRIM
| ID: wpr-491943
المكتبة المسؤولة:
WPRO
ABSTRACT
Alzheimer′s disease(AD)is a degenerative metabolic disease,whose exact pathological mechanism still remains unknown. Currently,studies have found that patients in AD accompany with insulin signaling pathway impairment and cerebral glu?cose metabolism dysfunction. As insulin signaling pathway and cerebral glucose metabolism homeostasis play a key role in AD ,some researches consider AD as“typeⅢdiabetes”. This review aims to discuss the alteration of cerebral insulin signaling pathway and glu?cose metabolism in AD,as well as their relationship with AD. We will also elaborate the advance in anti-AD drugs based on cerebral insulin signaling pathway.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Journal of International Pharmaceutical Research
السنة:
2016
نوع:
Article