Lymphoma and cAMP signaling pathway / 中国癌症杂志
China Oncology
; (12): 556-560, 2016.
Article
ي Zh
| WPRIM
| ID: wpr-495788
المكتبة المسؤولة:
WPRO
ABSTRACT
Several signaling pathways are involved in clonal proliferation of lymphoma cells and disease progression. It has been shown that cyclic adenosine monophosphate (cAMP) signaling pathway, as an important intra-cellular messenger delivery system, is related to modulation of multiple physiological processes including cell prolifer-ation, secretion, metabolism and apoptosis. Manipulating the cAMP signaling pathway can induce cell cycle arrest and apoptosis of various malignant lymphoid cells, which involves mitochondria-dependent apoptosis and cAMP-modulated protein kinases as well as changes of intracellular mediators. In-depth research and analysis of cAMP-induced apoptosis in lymphoma cells would provide potential targets and possible therapeutic means for the treatment of lymphoma.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
China Oncology
السنة:
2016
نوع:
Article