Efficacy and safety of Sanhuang gancao mixture combined with antibiotics in purulent meningitis / 中国生化药物杂志

ABSTRACT

Objective To observe the efficacy and safety of Sanhuang gancao mixture combined with antibiotics in the treatment of children with purulent meningitis.Methods 52 cases with purulent meningitis were randomly and double-blindly divided into observation group and control group of 26 cases in each group.The control group received ceftriaxone sodium treatment, observation group received Sanhuang gancao mixture combined with ceftriaxone sodium therapy.The tumor necrosis factor (TNF-α), high-sensitivity C-reactive protein (hs-CRP) and white blood cell (WBC) levels in cerebrospinal fluid and dispearance time of related symptoms, therapeutic effect and adverse reactions in two groups were observed before and after treatment.Results After treatment, the TNF-α, hs-CRP and WBC levels in cerebrospinal fluid of observation group were lower than the control group (P<0.05).The time returning to normal temperature, time of consciousness recovery, time of cerebrospinal fluid returning to normal, dispearance time of intracranial hypertension were shorter than control group (P<0.05).The total efficacy in observation group was higher than control group(P<0.05). There existed adverse reactions in two groups but had no significant difference.Conclusion Sanhuang gancao mixture combined with antibiotics could reduce the inflammatory, return white cells to normal and accelerate the recovery process of sign whose efficacy is better than antibiotics alone without increasing the adverse reactions in the treatment of children with purulent meningitis.