Research on the expression of Caveolin-1 with EGFR mutations in non-small cell lung cancer tissues and its clinical significance / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 498-502, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-499205
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective This study aims to examine expression of Caveolin -1 in non smoking cell lung cancer(NSCLC)and to discusses the relationship between expression of Caveolin -1 and the Epidermal growth factor receptor mutations .Methods Immunohistochemical staining was used to determine the Caveolin -1 ex-pression and ARMS-qPCR was used to measure EGFR mutations in 40 cases of lung cancer tissue .The clinical pathological characteristics and correlations in patients were analyzed .Results The expression of Caveolin -1 in human lung cancer was significantly lower than that in normal lung tissue ,and negatively correlated with EGFR mutations ,which was statistically significant .Conclusion Caveolin -1 expression is negatively correlated with EGFR mutations in non-small cell lung cancer and related to the histologic type .Caveolin-1 may be a molecu-lar target for diagnosis and judgment of NSCLC .
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Practical Oncology Journal
السنة:
2014
نوع:
Article