The research progress of survivin targeted therapy in cancer research / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 165-169, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-499421
المكتبة المسؤولة:
WPRO
ABSTRACT
Survivin,the smallest and structurally unique member of the inhibitor of apoptosis protein (IAP)family,is highly expressed during fetal development and rarely expressed in self -renewable healthy adult tissues.Moreover,it exists in most malignant tissues .Survivin is described as a bifunctional protein involving in the regulation of cell proliferation and apoptosis in normal and cancer cells .Due to its structural and functional distinctiveness ,survivin is currently attracting considerable attention as a new target for cancer molecular targeted therapy.Strategies to targeting Survivin include antisense oligonucletides ,ribozymes,siRNA,dominant negative mutants,small molecule antagonists and immunotherapy .
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Practical Oncology Journal
السنة:
2014
نوع:
Article