Quantitative proteomics of CDC42 in HBx-mediated cellular transformation / 军事医学
Military Medical Sciences
; (12): 697-702, 2016.
Article
ي Zh
| WPRIM
| ID: wpr-503989
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective To identify the mediators of CDC42 signaling pathway involved in hepatitis B virus X protein (HBx)-mediated cellular transformation.Methods The mass defect-based pseudo-isobaric dimethyl labeling method (pIDL)was used to detect the differentially expressed proteins with a deficiency of CDC42.Furthermore,we conducted a gene ontology (GO)of differentially expressed proteins.Results and Conclusion We totally qualified 3409 proteins and found 220 differentially expressed proteins.Palladin,formin-like 1 (FMNL1)and keratin-19,which were implicated in cytoskeleton organization,were down-regulated with the deficiency of CDC42.Our results have provided candidate genes and proteins that may play an important role in HBx-mediated cellular transformation.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Military Medical Sciences
السنة:
2016
نوع:
Article