Epidemiologic and clinical features in children with acute lower respiratory tract infection caused by human metapneumovirus in 2006-2007 / 소아과
Korean Journal of Pediatrics
; : 330-338, 2009.
Article
ي Ko
| WPRIM
| ID: wpr-53299
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE:
The causes of acute lower respiratory tract infection (ALRTI) are mostly attributable to viral infection, including respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A/ B (IFV A/ B), or adenovirus (ADV). Several Korean studies reported human metapneumovirus (hMPV) as a common pathogen of ALRTI. However, studies on seasonal distribution and clinical differences relative to other viruses are insufficient, prompting us to perform this study.METHODS:
From November 2006 to October 2007, we tested nasopharyngeal aspiration specimens in children hospitalized with ALRTI with the multiplex reverse transcriptase-polymerase chain reaction to identify 6 kinds of common pathogen (hMPV, RSV, PIV, IFV A/ B, and ADV). We analyzed positive rates and clinical features by retrospective chart review.RESULTS:
We detected 38 (8.4%) hMPV-positive cases out of 193 (41.8%) virus-positive specimens among 462 patients. HMPV infection prevailed from March to June with incidence peaking in April. HMPV-positive patients were aged 1-5 years (76.3%), and the ratio of boys to girls was 1.21. The median age was 27 months. HMPV primarily caused pneumonia (76.3%) (P=0.018). Average hospitalization of HMPV-associated ALRTI patients was 5.8 days. In addition, they showed parahilar peribronchial infiltration (100%) on chest X-ray, normal white blood cell count (73.7%), and negative C-reactive protein (86.8%) (P>0.05). All hMPV-positive patients recovered without complication.CONCLUSION:
HMPV is a common pathogen of ALRTI in Korean children, especially in 1-5 year olds, from March to May. Immunocompetent children diagnosed with hMPV-associated ALRTI may have a good prognosis.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Orthomyxoviridae
/
Pneumonia
/
Prognosis
/
Respiratory Syncytial Viruses
/
Respiratory System
/
Respiratory Tract Infections
/
Seasons
/
Thorax
/
Viruses
/
C-Reactive Protein
نوع الدراسة:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
المحددات:
Aged
/
Child
/
Humans
اللغة:
Ko
مجلة:
Korean Journal of Pediatrics
السنة:
2009
نوع:
Article