The Effect of Chronic Intermittent Hypoxia on Cognition and the Expression of Insulin-like Growth Factor-1 in CA1 Region of Hippocampus / 中国临床心理学杂志

ABSTRACT

Objective: To study the effect of chronic intermittent hypoxia on cognitive functions in Sprague-Dawley rats and the expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus.Methods: Experiments were performed on 16 three-month-old male Sprague-Dawley rats,They were randomly assigned to two experimental groups(n=8/group): chronic intermittent hypoxia group(CIH),and unhandled control group(UC).Rats in UC group were raised normally,and those in CIH group suffered 7H intermittent hypoxia everyday,The duration of experiment was 8 weeks.The learning and memory ability of rats in each group were assessed with the Morris water maze test at the end of the experiments.The expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus was investigated by immunohistochemistry staining and image analysis.Results: ①Morris water maze test learning scores(place navigation): After 5 days training,the escape latency in CIH rats was significantly longer than that in UC rats(P