EFFECTS OF ABDOMINAL VAGAL AFFERENTS ON THE SOMATOSTATIN CONCENTRATION IN AMYGDALA, HYPOTHALAMIC NUCLEI AND STOMACH OF RATS / 第二军医大学学报

ABSTRACT

Effects of cutting the ventral trunk of abtominal vagus nerve of rats. and stimulating its central end on the somatostatin concentration in amygdala, hy-pothalamic nuclei and stomach were studied by radioimmunoassay.Following section of the vagus nerve, the somatostatin concentration of amygdaloid nuclei was not changed, that of lateral preoptic area, hyopthalamic ventromedial nuclei and paraventricular nuclei was reduced, and that of mucosal and muscular layers of antrum and corpus of stomach was also decreased, indicating the tonic influence of the vagus nerve impulses on hypothalamic and gastric somatostatin concentration. Electrical stimulation of the central end of the vagus nerve decreased the somatostatin concentration of medial, lateral and central amygdala, increased that of lateral preoptic area, hypothalamic ventromedial and paravcntricular nuclei, and also increased that of mucosal and muscular layers of gastric antrum, suggesting that somatostatin in amygdala and hypothalamic nuclei plays a role in central integration of visceral afferent information.