Effects of Ventromedial Hypothalamic Somatostatin on Gastric Somatostatin and Acid Secretion in Rats / 第二军医大学学报

ABSTRACT

The effects of somatostatin and cysteamine injccted into the ventromedial nucleus of the hypothalamus (VMH) on somatostatin-like immunoreactivity (SLI) concentration in the gastric antral mucosa and portal vein plasma as well as the gastric acid secretion were studied in anesthetized rats. The SLI concentration in the gastric antral mucosa and portal vein plasma and the gastric acid output were significantly increased one hour after injection of somatostatin (o. 5 ?g/0.5 ?l) into the VMH. Four hours later, the SLI concentration in the mucosa was still higher than the control level, while the SLI level in the plasma and the acid secretion were close to those of controls. On the contrary, the SLI concentration in the mucosa and plasma and the acid output were markedly decreased at four hours after injection of cysteamine (15?g/0.5?l) into the VMH. The present results suggest that both exogenous and endogenous somatostatin in the VMH have a facilitory action on the gastric somatostatin concentration and its release as well as on the gastric acid secretion, thus providing evidence for hypothalamic control of gastric somatostatin and acid secretion.