Effect of Curcumin and TSA on Human Gastric Cancer Cell Line c-myc Expression / 医学研究杂志
Journal of Medical Research
; (12)2006.
Article
ي Zh
| WPRIM
| ID: wpr-567570
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective To understand the effect of curcumin and TSA on c-myc gene expression in human gastric cancer and to explore the dynamic balance of the histone acetylation / deacetylation in gene expression in gastric cancer and the significance of the regulation. Methods Gastric cancer cell line SGC-7901 and MGC803 were cultured,and then different concentrations of histone acetylase inhibitors curcumin and histone deacetylase inhibitor TSA were added,respectively.mRNA of c-myc expression wasdetected by RT-PCR. Results With increasing of the concentration of curcumin and redcuing of the TSA concentrations c-myc expression was inhibited (P
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Journal of Medical Research
السنة:
2006
نوع:
Article