Muscle relaxation of cisatracurium besilate made in China on adult patients / 重庆医科大学学报

ABSTRACT

Objective:To determine the clinical pharmacokinetics of cisatracurium besilate,and its effects on hepatic function and renal function in Chinese patients.Methods: Thirty ASA Ⅰ～Ⅲ,patients undergoing elective surgery were enrolled in this study.Anesthesia was induced by a single injection of cisatracurium 0.15mg/kg.The change of heart rate,blood pressure,skin condition and TOF were observed.When T1 reached the maximum block effect,condition of intubation were appraised and recorded.The inhibition and recovery process of adductor pollicis muscle to stimulation of ulnar nerve with TOF pulses was recorded.Times to T4/T1 inhibition and recovery to 25%,75% and 100% were noted.Which were the observing index for muscle relaxation.Hepatic function and renal function were determined after 24 hours.Results: AS the maximum block effect was 100%intubation completed.Grade one was 93.3%(28cases),and grade two was 6.7(% 2cases).No erubescent phenomenon and bronchitis spasm were discovered.After induction of anesthesia,HR and BP decreased significantly(P