Relation between the expression of RAR?,RAR? and endometrial carcinoma / 重庆医科大学学报

ABSTRACT

Objective:To evaluate the role of the retinoic acid receptor ?(RAR?),retinoic acid receptor ?(RAR?) in the devel-opment and prognosis of the endometrial carcinoma by detecting the expression of these receptors. Methods:48 cases of paraffin-embedded tissues were selected, including 42 cases of adenocarcinoma and 6 cases of adeno-squamous carcinoma of endometrium. Immunohistochemistry was used to detect the level of RAR? and RAR?. The relation between the expression of these receptors and the clinical pathological parameters was evaluated. Results:The positive expression ratios of the RAR? and RAR? were 47.92%(23/48)and 25.00%(12/48),respectively. The level of RAR? was significantly higher than that of RAR?(P0.05). The level of the RAR? decreased with the increasing of the malignancy extent of the endome-trial adenocarcinoma(P0.05)respectively. Conclusion:There is close relation between the ex-pression of the RAR? and the development of the endometrial carcinoma. The defect of the RAR? and the high expression of the RAR? indicates a bad prognosis of the endometrial carcinoma. Detection of these two is benefited receptors together for us to estimate the prognosis of the carcinoma.