Effect of Granulocyte (-Macrophage) Colony-Stimulating Factor on Oral Mucositis Due to Concomitant Chemoradiotherapy in Locally Advanced Head and Neck Cancer Patients / 中国肿瘤生物治疗杂志
Chinese Journal of Cancer Biotherapy
; (6)1996.
Article
ي Zh
| WPRIM
| ID: wpr-583388
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective:
To evaluate the efficacy of granulocyte(-macrophage) colony stimulating factor[G(M)-CSF] inthe treatment of concomitant chemoradiotherapy-induced oral mucositis in locally advanced head and neck cancer patients.Metheds Fifteen patients with locally advanced head and neck cancer was received concomitant chemoradiotherapy, whilewhite blood cell count were less than 1. 5?10~9/L with grade Ⅲ/Ⅳ oral mucositis, they were subcutaneously given G(M)-CSF at dose of 100-300?g daily for 3~10 days.Results:
After administration of G(M)-CSF, all of the patients had anaugmantation of white blood cell count more than 5. 0?10~9/L. Complete healing of oral mucositis occurred in 1 patient(CR), partial in 8 patients(PR), whereas 6 patients had no change and none was progressive, the objective response rate(CR+PR) was 60%. Condusions G(M)-CSF is proved effective for oral mucositis caused by concomitant chemoradio-therapy in locally advanced head and neck cancer patients.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Chinese Journal of Cancer Biotherapy
السنة:
1996
نوع:
Article