Effect of bone marrow mesenchymal stem cells on repairment of carotid artery endothelium injured by balloon in rats / 中国介入心脏病学杂志

ABSTRACT

Objective To investigate the effect of bone marrow mesenchymal stem cells(MSCs) transplation on reparing carotid artery endothelium in S-D rat injured by balloon.Methods Twenty four male Sprague-Dawley(SD) rats underwent balloon overstretch injury in the right common carotid artery and were randomly divided into treatment group(MSCs suspension injected) and control group(phosphate buffered solution injected).Animals were killed to assess vessel morphology and histology at 14 and 28 days after injury in the two groups.Results By H-E staining,morphometric analysis at 14 and 28 days showed that MSCs injection after balloon injury significantly reduced neointimal thickening compared with PBS injection after balloon injury [(0.57?0.06) cm vs(1.09?0.07) cm at 14 days,P