Drug-resistance Analysis of Acinetobacter baumannii between 2001-2006 / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To study the changing trends of drug-resistance of Acinetobacter baumannii isolates.METHODS All 668 isolates of A.baumannii were obtained from clinical patients in the First Affiliated Hospital of China University of Sciences Medical between 2001-2006.K-B test was used to determine the susceptibility and the results were read based on National Committee for Clinical Laboratory Standards(NCCLS)of the USA.RESULTS The number of A.baumannii isolates was increasing from 61 in the year of 2001 to 247 in the year of 2006.And during the six years,the resistant rate to ciprofloxacin,gentamicin and imipenem was increasing from 28.8%,25.4%,5.4% to 64.9%,72.7% and 48.5%,respectively.The resistant rate of the 50 multidrug-resistant A.baumannii isolates to polymyxin B was 18.6%.CONCLUSIONS During the six years,the isolating rate is increasing,the result showed that there is not a large scale outbreak.The resistant rate is so high that we must strengthen the monitoring and indentify the drug-resistance mechanisms.