Effect of Membrane-coating on Dissolution and Stability of Sirolimus Dropping Pills / 中国药师
China Pharmacist
; (12): 1846-1848,1849, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-600336
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective:
To study the effect of membrane-coating on dissolution and stability of sirolimus ( SRL) dropping pills to prove the effect and rationality of the coating process.Methods:
Opadry was used as the coating material for SRL dropping pills. Com-pared with those of uncoated SRL dropping pills, the dissolution and stability of membrane-coating SRL dropping pills were studied in vitro.Results:
Compared with that of uncoated SRL dropping pills, the drug release amount of membrane-coating SRL dropping pills was lower (P0. 05). After the membrane-coating, the stability of SRL dropping pills was notable enhanced under high humidity (75% ± 5%) and strong light (4500lx ± 500lx) conditions, however, the stability showed no improved under high temperature(40℃ ± 2℃) condition.Conclusion:
The membrane-coating can enhance the stability of SRL dropping pills without significant effect on drug release in vitro.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
China Pharmacist
السنة:
2014
نوع:
Article