Colonic Mucosal Necrosis Following Administration of Calcium Polystryrene Sulfonate (Kalimate) in a Uremic Patient
Journal of Korean Medical Science
; : 1207-1211, 2009.
Article
ي En
| WPRIM
| ID: wpr-63986
المكتبة المسؤولة:
WPRO
ABSTRACT
Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol. We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man. He had a history of hypertension and uremia. During the management of intracranial hemorrhage, hyperkalemia developed. Kalimate was administered orally and as an enema suspended in 20% dextrose water to treat hyperkalemia. Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon. Microscopic examination of random colonic biopsies by two consecutive sigmoidoscopies revealed angulated crystals with a characteristic crystalline mosaic pattern on the ulcerated mucosa, which were consistent with Kayexalate crystals. Hematochezia subsided with conservative treatment after a discontinuance of Kalimate administration.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Polystyrenes
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Uremia
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Colon
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Gastrointestinal Hemorrhage
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Hyperkalemia
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Intestinal Mucosa
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Necrosis
المحددات:
Adult
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Humans
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Male
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2009
نوع:
Article