IGF-I and -II production during menstrual cycle / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 1515-1526, 2006.
Article
ي Ko
| WPRIM
| ID: wpr-64295
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE:
We designed this study to understand the physiologic effects and secretory pattern of IGF-I and IGF-II in human serum and changes in expression of IGF-I and IGF-II in human ovarian tissues during menstrual cycle, and to know which one is more important on human ovarian function between IGF-I and IGF-II, related to FSH, LH and estradiol.METHODS:
IGF-I, IGF-II, FSH, LH and estradiol levels were measured in 80 serum samples by ELISA from normal reproductive women. We also examined the immunohistochemical staining of the IGF-I and IGF-II in the ovarian tissues of 14 normal reproductive women. The mean age was 35.6+/-9.15 years-old, ranged from 20 to 45. The average menstrual cycle was 27 to 29 days.RESULTS:
1. The average serum concentration of IGF-I was 204.43+/-50.92 ng/mL, and that of IGF-II was 1381.56+/-292.56 ng/mL. 2. The regular pattern or relationship on serum IGF-I and IGF-II concentrations were not observed (P=0.19). 3. To cross-correlation of serum concentrations of FSH, LH, estradiol and IGF-I, IGF-II, IGF-II was thought to effect on human ovarian menstrual cycles, affected by action of FSH (P=0.048). 4. In the normal reproductive ovaries, we observed immunohistochemical staining for IGF-I in primary, secondary, mature follicle, corpus luteum and stroma, but not in corpus albicans. 5. In the normal reproductive ovaries, we observed immunohistochemical staining for IGF-II in primary, secondary, mature follicle, and corpus luteum but not in corpus albicans and stroma. 6. Stronger immunohistochemical staining was observed in ovaries for IGF-II, rather than IGF-I.CONCLUSION:
IGF-I and IGF-II were produced by ovarian tissues, and participated in ovarian folliculogenesis according to menstrual cycles by paracrine, autocrine functions. IGF-II, rather than IGF-I, was thought to effect greater on human ovarian menstrual cycles, affected by action of FSH.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Ovary
/
Insulin-Like Growth Factor I
/
Insulin-Like Growth Factor II
/
Enzyme-Linked Immunosorbent Assay
/
Immunohistochemistry
/
Corpus Luteum
/
Estradiol
/
Ovarian Follicle
/
Menstrual Cycle
المحددات:
Female
/
Humans
اللغة:
Ko
مجلة:
Korean Journal of Obstetrics and Gynecology
السنة:
2006
نوع:
Article