Correlation between serum cytokine IL-17 and demyelinating neuropathy multiple sclerosis:a Meta-analysis / 中国免疫学杂志

ABSTRACT

Objective:To evaluate the association with serum Interleukin-17 ( IL-17 ) and multiple sclerosis ( MS ) systematically evaluated .Methods:The retrieval words of "multiple sclerosis or MS"and "interleukin-17 or IL-17"were searched in PubMed,SpringerLink,Embases,OVID,China National Knowledge infrastructure (CNKI),Chinese VIP database,Chinese Biomedical Literature Database (CBM),Wan Fang Database through computer.Review Manager 5.3.was selected as the software edition.The time frame was ranged from January 1,2000 to March 10,2017.The language was not restricted .Results: Eventually 8 case-control studies were included with 544 cases.We found that the serum IL-17 level was associated with MS according to the weighted mean difference and 95%confidence interval ( WMD =38.65;95%CI:18.66 ,58.63 ) ,which had significant difference in statistics .Conclusion:The serum IL-17 level increases the risk of MS , suggesting that the serum IL-17 level can be used as a predictive biomarker for MS development and a target for MS effective prevention and treatment .