Effects of quercetin on metabolism of cyclooxygenase in IEC-6 cells stimulated by the serum of burned rats / 第三军医大学学报
Journal of Third Military Medical University
; (24)2003.
Article
ي Zh
| WPRIM
| ID: wpr-678460
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective To observe the effects of quercetin on PGE 2 release and cyclooxygenase activity in IEC 6 cells stimulated by the serum of burned rats. Methods The PGE 2 levels were measured by radioimmunoassay and the changes of cyclooxygenase activity were determined by substrate fluorescence analysis. Results Stimulated by the serum of burned rats, the PGE 2 level increased first and then obviously decreased. Quercetin at 0.1 and 1.0 ?mol/L enhanced the PGE 2 level after the stimulation of IEC 6 cells for 24 h. There was no obvious change in total cyclooxygenase activity, but the activity ratio of COX 1 to COX 2 significantly decreased. Conclusion Quercetin might influence the release of cyclooxygenase metabolite PGE 2 through the regulation of COXs activity in IEC 6 cells.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Journal of Third Military Medical University
السنة:
2003
نوع:
Article